Nitric Oxide Synthase Inhibitor N-nitro-L-arginine Methyl Ester Impair Fertility of Female Rats When Given during Early Pregnancy

dc.contributor.author	Ratnasooriya, W.D.
dc.contributor.author	Jayakody, J.R.A.C.
dc.contributor.author	Kalubowila, D.G.W.
dc.date.accessioned	2013-04-23T02:29:44Z
dc.date.available	2013-04-23T02:29:44Z
dc.date.issued	2001
dc.identifier.citation	Ratnasooriya, W.D., Jayakody, J.R.A.C., & Kalubowila, D.G.W. (2001). Nitric Oxide Synthase Inhibitor N-nitro-L-arginine Methyl Ester Impair Fertility of Female Rats When Given during Early Pregnancy. Vidyodaya Journal of Science, 10, 127-134.	en-US
dc.identifier.uri	http://dr.lib.sjp.ac.lk/handle/123456789/1002
dc.description.abstract	The role of nitric oxide (NO) on fertility of female rats was investigated by oral administration of the NO synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) (50 or l00mg/kg/day) to rats from days 1-7 of gestation. L-NAME caused a moderate but significant reduction (P<0.05) in number of uterine implants. This antifertility effect was due to an elevation in pre-implantation loss. The inactive stereoisomer D-NAME, on the other hand, had no effect whatsoever on fertiligy. The results suggest that NO is essential for the expression of normal fertility in female rats and NO donors may find applications in the treatment of some forms of female subfertility.	en_US
dc.language.iso	en	en_US
dc.subject	N-nitro L-arginine methyl ester (L-NAME)	en_US
dc.subject	Nitric oxide	en_US
dc.subject	Nitric oxide synthase	en_US
dc.subject	Fertility	en_US
dc.subject	Pre-implantation loss	en_US
dc.title	Nitric Oxide Synthase Inhibitor N-nitro-L-arginine Methyl Ester Impair Fertility of Female Rats When Given during Early Pregnancy	en_US
dc.type	Article	en_US
dc.date.published	2001