DSpace Repository

Graphene OxideeBased Nanocomposite for Sustained Release of Cephalexin

Show simple item record

dc.contributor.author Katuwavila, N.P.
dc.contributor.author Amarasekara, Y.
dc.contributor.author Jayaweera, V.
dc.contributor.author Rajaphaksha, C.
dc.contributor.author Gunasekara, C.
dc.date.accessioned 2022-08-17T07:07:54Z
dc.date.available 2022-08-17T07:07:54Z
dc.date.issued 2019
dc.identifier.citation Katuwavila, N.P., et al. (2019). Graphene OxideeBased Nanocomposite for Sustained Release of Cephalexin. Journal of Pharmaceutical Sciences xxx (2019) 1-6 en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/11694
dc.description.abstract A sustained-release carrier system for the drug cephalexin (CEF) using functionalized graphene oxide is reported. PEGylation of GO (GO-PEG) and successful loading of CEF into PEGylated graphene oxide (GOPEG-CEF) nanoconjugate are confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis. Encapsulation efficiency of 69% and a loading capacity of 19% are obtained with the optimized formulation of GO-PEG-CEF. In vitro CEF release profiles show an initial burst release followed by a more sustained release over a 96 h period with cumulative release of 80%. The half maximal inhibitory concentration (IC50) values have both dose- and time-dependent antibacterial activity for GOPEG-CEF against both gram-positive and gram-negative bacteria while pure CEF showed only dosedependent antibacterial activity. The minimum inhibitory concentration values of GO-PEG-CEF are 7.8 and 3.9 mg/mL against S. aureus and B. cereus, respectively, while it is 10 mg/mL with pure CEF against both gram-positive bacteria. This confirms the enhanced antibacterial activity of GO-PEG-CEF over pure CEF against gram-positive bacteria. These findings therefore show GO-PEG-CEF is promising as a sustainedrelease nanoantibiotic system for effective treatment against S. aureus and B. cereus infections en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject graphene drug delivery system(s) nanodrug(s) nanomedicine nanocomposite(s) nanoparticle(s) nanotechnology multidrug resistance controlled release drug resistance en_US
dc.title Graphene OxideeBased Nanocomposite for Sustained Release of Cephalexin en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account