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Antimicrobial and Alpha-Amylase Inhibitory Activities of Organic Extracts of Selected Sri Lankan Bryophytes

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dc.contributor.author Kirisanth, A.
dc.contributor.author Nafas, M.N.M.
dc.contributor.author Dissanayake, R.K.
dc.contributor.author Wijayabandara, J.
dc.date.accessioned 2022-08-31T05:58:53Z
dc.date.available 2022-08-31T05:58:53Z
dc.date.issued 2020
dc.identifier.citation Kirisanth, A., et al. (2020). Antimicrobial and Alpha-Amylase Inhibitory Activities of Organic Extracts of Selected Sri Lankan Bryophytes. Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 3479851, 6 pages en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/11872
dc.description.abstract Medicinal plants have been the main focus of natural product research. However, recent research has revealed that lower plants including bryophytes are also a major resource of biologically active compounds with novel structures. Sri Lanka is considered as a biodiversity hotspot with a higher degree of endemism flora including bryophytes. In this study, different species of bryophytes were investigated for their antimicrobial and alpha-amylase inhibitory activities. (e air-dried plant materials of 6 different bryophyte species, Marchantia sp., Fissidens sp., Plagiochila sp., Sematophyllum demissum, Hypnum cupressiforme, and Calymperes motley, were subjected to sequential cold extraction with 3 different organic solvents. All three types of organic crude extracts were subjected to screening of antimicrobial bioassays using the disc-diffusion method against 3 bacterial strains and 1 fungal strain. According to the results obtained, 6 extracts out of 18 showed antibacterial activity for tested Gram-positive bacteria and 1 active against Gram-negative bacteria. Two extracts showed activity against the pathogenic fungus strain. Extracts from some plants were active against tested bacterial as well as fungal species. TLC-based bioautographic study was carried out to identify the corresponding active bands which is useful for active compound isolation. Furthermore, the ethyl acetate extracts were subjected to evaluate alpha-amylase inhibitory activity where three extracts out of six extracts showed moderate inhibitory activity for alpha-amylase with IC50 ranging 8–30%. en_US
dc.language.iso en en_US
dc.publisher Hindawi en_US
dc.title Antimicrobial and Alpha-Amylase Inhibitory Activities of Organic Extracts of Selected Sri Lankan Bryophytes en_US
dc.type Article en_US


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