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PRODUCTION, ISOLATION AND CHARACTERIZATIONOF TRICHOTHECENES FROM FUNGI

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dc.contributor.author Yatawara, C.S.
dc.date.accessioned 2016-09-22T08:07:40Z
dc.date.available 2016-09-22T08:07:40Z
dc.date.issued 2016-09-22T08:07:40Z
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/2903
dc.description.abstract Attached en_US
dc.description.abstract Several Myrothecium isolates have been investigated with respect to their ability to produce macrocyclic trichothecene esters. Myrothecium verrucaria CL-72 in liquid culture produces roridin Hand isororidin E as the major metabolites. M. ~oridum isolate 4582 produces no macrocyclic or trichoverroid trichothecenes, in solid or liquid media but instead produces only simple trichothecenes, the principal one of which is 7a-hydroxytrichodermol. On rice substrate, M. roridum CL-514 (ATCC 20605) was found to produce a new class of macrocyclic trichothecenes known as roritoxins. The roritoxins (A-D) contain a tetrahydropyranyl ring fused to a y-lactone or lactol ring in the macrolide sidechain and are analogous in structure to vertisporin except that the roritoxins contain the Z,E-diene system common to most of the macrocyclic trichothecenes. Roritoxin C is unique in that it possesses a 9B,10~epoxide group which heretofore has never been found naturally in trichothecenes isolated from fungal sources. In liquid medium, M. roridum CL-5l4 (ATCC 20605) produces yet another new antibiotic which was found to be an isomer of epiepoformin and named as isoepiepoformin «+)-(lR,5S,6R)-5-hydroxy-4-methyl-7-oxabicyclo[4.l.0)hept3-3n-2-one.) Fermentation on rice substrate of a S. atra isolate (Dl132) le~ to the isolation of trichoverrols A and B in addition to the expected trichothecenes roridin E and satratoxins F, G and H, strengthening the idea that trichoverrols A and Bare biosynthetic precursors to the macrocyclic trichothecenes. The yields of satratoxins also were greatly improved in this fermentation. Verrucarin B, verrucarin J, satratoxin Hand trichoverrins A and B were isolated from a field sample obtained from a house in suburban Chicago, Illinois, where the occupants of the house were complaining of maladies similar to those observed in trichothecene toxicosis. The fact that trichothecenes were isolated from the field sample itself and not from the laboratory growth of the problem-causing fungus makes this isolation important. Also this is the first time that stachybotryotoxicosis has been reported in North America.
dc.language.iso en en_US
dc.title PRODUCTION, ISOLATION AND CHARACTERIZATIONOF TRICHOTHECENES FROM FUNGI en_US
dc.type Article en_US
dc.date.published 1985


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