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Effect of Aqueous Soluble Proanthocyanidins from Cocos Nucifera L. Inflorescence on Progesterone and Oestrogen Levels in Female Rats

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dc.contributor.author Padumadasa, C.
dc.contributor.author Dharmadana, D.
dc.contributor.author Abeysekera, A.M.
dc.contributor.author Thammatiyagoda, M.G.
dc.date.accessioned 2017-03-27T03:37:16Z
dc.date.available 2017-03-27T03:37:16Z
dc.date.issued 2015
dc.identifier.citation Padumadasa, C., Dharmadana, D., Abeysekera, A.M., & Thammatiyagoda, M.G., (2015). Effect of Aqueous Soluble Proanthocyanidins from Cocos Nucifera L. Inflorescence on Progesterone and Oestrogen Levels in Female Rats. Asian Journal of Phytomedicine and Clinical Research, 3(4), 111-116. en_US, si_LK
dc.identifier.issn 2321-0915
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/4581
dc.description.abstract The immature inflorescence of Cocos nucifera L. variety aurantiaca is used by Ayurvedic and traditional medical practitioners for the treatment of menorrhargia in Sri Lanka. We have previously reported the effect of ethyl acetate soluble proanthocyanidins (EASPA) of the inflorescence of Cocos nucifera L. on reproductive hormone levels of female rats in relation to its ethno medical usage. AQSPA obtained from immature Cocos nucifera L. (var. aurantiaca) inflorescence was evaluated for its effect on the reproductive hormonal levels of female rats. AQSPA (2.8 mg/day) dissolved in water was administered orally to female rats for 28 consecutive days. At the end of the study period, oestrogen and progesterone levels were measured and compared with the control group (water). Statistical analysis was performed with one-way ANOVA, followed by student T test using Minitab 17.0 software. The length of the reproductive cycle was 4.89 ± 0.21 days and 4.37 ±0.16 days for the control and test group rats, respectively. No significant changes were noticed in the length of the cycle nor were there any difference in vaginal cytology in test and control group rats. There were no significant difference in both estrogen and progesterone levels between control and test group animals. This may be as a result of low bioavailability of AQSPA due to its high molecular weight profile. In addition, this may also be due to an inadequacy of the dose or time duration that AQSPA was administered. en_US, si_LK
dc.language.iso en en_US, si_LK
dc.subject Cocos nucifera inflorescence en_US, si_LK
dc.subject Menorrhagia en_US, si_LK
dc.subject Proanthocyanidins en_US, si_LK
dc.subject Progesterone en_US, si_LK
dc.title Effect of Aqueous Soluble Proanthocyanidins from Cocos Nucifera L. Inflorescence on Progesterone and Oestrogen Levels in Female Rats en_US, si_LK
dc.type Article en_US, si_LK


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