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Currently, there is an increased scientific interest to discover plant based drug formulations with improved therapeutic potential. Among the cornucopia of traditional medicinal plants, Curcuma longa rhizomes have been used as a
powerful antibacterial and antifungal agent. However, its practical applications are limited due to its instability under
thermal and UV radiation and its low bioavailability and the extensive procedures needed for isolation. This study
focuses on exploring the potential of nanotechnology-based approaches to stabilize the natural curcuminoids, the
major active components in turmeric without the need for its isolation, and to evaluate the release characteristics,
stability and antimicrobial activity of the resulting nanohybrids. Natural curcuminoids were selectively encapsulated
into nanolayers present in Mg–Al-layered double hydroxides (LDHs) using a method that avoids any isolation of the
curcuminoids. The products were characterized using solid state techniques, while thermal and photo-stability were
studied using thermogravimetric analysis (TGA) and UV exposure data. The morphological features were studied
using scanning electron microscope (SEM) and transmission electron microscope (TEM). Drug release characteristics of the nanohybrid were quantitatively monitored under pH 3 and 5, and therapeutic potentials were assessed
by using distinctive kinetic models. Finally, the antimicrobial activity of curcuminoids-LDH was tested against three
bacterial and two fungal species. Powder X-ray diffraction, Fourier transform infra-red spectroscopy, SEM and TEM data
confirmed the successful and selective encapsulation of curcuminoids in the LDH, while the TGA and UV exposure
data suggested the stabilization of curcuminoids within the LDH matrix. The LDH demonstrated a slow and a sustained release of the curcuminoids in an acidic medium, while it was active against the three bacteria and two fungal
species used in this study, suggesting its potential applications in pharmaceutical industry
