Attached
The aim of present study was to evaluate the cytotoxic effects of some
selected cyanotoxins namely, MC-IR, MC-RR, MC-LF, MC-LW and Nodularin
on normal human kidney cells (HEK-293) and human kidney adenocarcinoma
cells (ACHN). Cells were exposed to different concentrations of (1.0-200 pM)
cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by
Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate
that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was
the most toxic while MC-LW was least toxic cyanotoxin on both cell types
tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human
renal cells.
