Attached
Method
This prospective observational study
conducted in a tertiary-care hospital recruited
in-ward patients with NCCDs. All ADRs that
occurred during the index hospital admission
and in the 6-month period following discharge
were detected by active surveillance. Details
were recorded using the ADR reporting form,
developed based on the publication of the
Clinical Center, Pharmacy Department,
National Institutes of Health.
Results
715 patients were studied (females-50.3%,
mean age-57.6 years). The mean number of
medicines given per patient was 6.11±2.97.
The most prevalent NCCDs were hypertension
(48.4%; 346/715), diabetes (45.3%; 324/715)
and ischemic heart disease (29.4%; 210/715).
112 patients (15.7%) experienced at least one
ADR. In the 112 patients, 154 ADRs (33 during
index hospital admission; 121 during 6-month
period following discharge) were detected.
51.9% (80/154) of them were potentially
avoidable. 47% (73/154) of ADR swere Serious
Adverse Events (SAEs); 13 were life
threatening, 46 caused hospitalization and 14
caused disability. The most common causes
for re-hospitalization due to ADRs were
hypoglycemia due to anti-diabetic drugs
(17/46), bleeding due to warfarin (14/46) and
hypotension due to anti-hypertensives (6/46).
Conclusions
Incidence of ADRs was high in the study
population. A large proportion of them were
SAEs. The majority of ADRs that required rehospitalization were caused by widely used
medicines and were potentially avoidable.
