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A descriptive cross sectional study was conducted at Colombo South Teaching Hospital (CSTH) and Sri Jayewardenepura General Hospital (SJGH) to
describe knowledge and self-reported practices on post-operative pain management (POPM). Data were collected from a convenience sample of 132
nurses working in adult surgical wards using a pre-tested self-administered questionnaire. Data were analyzed using SPSS (version-16). Mean age and
years of experience of the participants were 32.5$7.7 and 7.0 $7.9 respectively. Those who had previous education on POPM were 87.1 %. The mean
score for overall knowledge was 64.9$ 1.4. The mean score for overall practices was 55.0$ 1.6. The participants had an average level of knowledge and
moderate level of self-reported practices on POPM. Most participants were knowledgeable on subjectivity of pain (58.3 %), use of pain scales for pain
assessment (79.5 %), and the need for administering analgesia round the clock(68.2%) while 75 % were unaware of measuring pain to assess analgesic
efficacy. A majority (56.1 %) were unaware of intravenous opioids being the best method to treat sudden onset of severe pain. Administration of opioids
were m in im i z e d by nurses $Always$ (50.8 %) and $Sometimes$ (42.4 %) because of the potential risk of patients becoming addicted. A total of 34.1
% nurses have given a placebo to patients to confirm the truth of their complaint on pain. Almost a half of the sample (48.5 %) has $Never$ used pain
scales but 70 % $always$ have asked about the presence of pain. Degree holders (p=0.000) and those who had previous education through in-service
training programs (p=0.048) had significantly high level of knowledge. Nurses who had work experience for more than 5 years (p=0.035) and previous
education on pain management (p=0.018) had significantly high practice scores. Provision of nursing knowledge through specific training on POPM may
contribute to improve nurses$ practices on POPM and hence to improve post-operative patient outcomes.