Attached
Introduction and objectives: Insulin is the most important regulator of glucose insulin is co-secreted with;
C-peptide from the pancreatic 6 cells It has been found
that men and women differ substantially in insulin resistance (IR) and metabolism of glucose The objective was
to determine gender differences in fasting serum insulin,
insulin resistance and fasting serum C-peptide. :
Method: The study population included males (n = 50)
and females (n = 50) aged 20-40 years. Study was conducted at Faculty of Medical Sciences (FMS), University
of Sri Jayewardenepura (USJP) Written consent was
obtained from participants. An interviewer administered
questionnaire was used to collect information. Fastjng
venous blood samples were obtained to analyse fasting
serum glucose (FSG), fasting serum insulin (FSI) anjd
C-peptide (C-pep). Glucose oxidase method was used
to measure plasma glucose level and ELISA method
was used for serum insulin assay and serum C-peptide
assay. Data were analysed using SPSS version 16 and
Microsoft Excel 2010. Significant differences were determined (p<0.05). :
Results: The whole study population had FSG levels'
below 100 mg/dL. The mean FSI levels in males and
females were 12.31 ±7.17 plU/mL and 12.39 ± 8.04jplU/
mL, mean C-pep levels were 4.57 ± 1 39ng/mL and 4.24
± 1 44ng/mL and Insulin resistance values were 2.41 ±
1.44 and 2.27 ± 1.66 respectively. The differences of FSI,
C-pep and IR between males and females were not significant (p>0.05).
Conclusion. This study did not observe a difference ih
insulin resistance, fasting serum insulin or C-peptidel between males and females
