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Atherosclerosis is the most important contributor to increasing burden of coronaiy artery disease
(CAD). Growing evidence suggests that the ratios of Apo B/Apo A-I and Lp(a) are better indexes for
risk assessm ent of CAD. Elevated plasma levels of lipoprotein(a) in humans represent a major inherited risk factor for atherosclerosis. Thus, a study was performed to determine the association
betwwen serum Apo B, Apo A-l, and lipoprotein(a) levels, and severity of CAD in patients with CAD
confirmed on coronary angiography findings. An analytical case control study was carried out with
85 patients (58 males and 27 females) 40 - 60 years of age confirmed as having CAD on coronary
angiography and 85 age and sex matched healthy volunteers as controls. Serum samples were
analyzed for Apo A -l LDL, Apo B, Apo A-I, and lipoprotein(a) concentration and the severity of CAD
was assessed using coronary angiography scoring method. Patients with CAD had significantly
high serum LDL-C, Apo B and Lp(a) levels compared to control subjects. However, serum Apo A-I
level did not show a significant difference between two groups. Subjects with a positive family
history of CAD with increased serum Lp(a) 2 17.3 mg/dL have high risk for development of CAD.
Present study suggests that serum Lp(a) cut-off value of 17.3 mg/dL may be an important predictor in ruling out major vessel disease and luminal narrowing by atheroma.
