The role of the unfolded protein response in dengue virus pathogenesis

dc.contributor.author	Perera, N.
dc.contributor.author	Miller, J.L.
dc.contributor.author	Zitzmann, N.
dc.date.accessioned	2017-11-09T08:47:26Z
dc.date.available	2017-11-09T08:47:26Z
dc.date.issued	2017
dc.identifier.citation	Perera, N., Miller, J.L., Zitzmann, N. (2017). "The role of the unfolded protein response in dengue virus pathogenesis", Cellular Microbiology, pp. 1-9	en_US, si_LK
dc.identifier.uri	http://dr.lib.sjp.ac.lk/handle/123456789/6748
dc.description.abstract	Attached	en_US, si_LK
dc.description.abstract	Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host‐viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a prosurvival cellular reaction induced in response to DENV‐mediated endoplasmic reticulum stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis, and innate immunity. DENV has evolved to manipulate the UPR to facilitate its replication and to evade host immunity. Our knowledge of this intertwined network of events is continuously developing. A better understanding of the UPR mediated antiviral and proviral effects will shed light on dengue disease pathogenesis and may help development of anti‐DENV therapeutics. This review summarizes the role of the UPR in viral replication, autophagy, and DENV‐induced inflammation to describe how a host response contributes to DENV pathogenesis.
dc.language.iso	en_US	en_US, si_LK
dc.publisher	Cellular Microbiology	en_US, si_LK
dc.subject	dengue	en_US, si_LK
dc.subject	unfolded protein response	en_US, si_LK
dc.subject	viruses (phages)	en_US, si_LK
dc.title	The role of the unfolded protein response in dengue virus pathogenesis	en_US, si_LK
dc.type	Article	en_US, si_LK