dc.contributor.author |
Padurnadasa, C. |
|
dc.contributor.author |
Xu, Y.M. |
|
dc.contributor.author |
Wijeratne, E.M.K. |
|
dc.contributor.author |
Artiles, P.E. |
|
dc.contributor.author |
U'Ren, J.M. |
|
dc.contributor.author |
Arnold, A.E. |
|
dc.contributor.author |
Gunatilaka, A.A.L. |
|
dc.date.accessioned |
2018-07-04T04:34:36Z |
|
dc.date.available |
2018-07-04T04:34:36Z |
|
dc.date.issued |
2018-01-26 |
|
dc.identifier.citation |
Padurnadasa, C., Xu, Y.M., Wijeratne, E.M.K., Artiles, P.E., U'Ren, J.M., Arnold, A.E., Gunatilaka, A.A.L. (2018). "Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa", Journal of Natural Products, Vol. 81, pp. 616-624 |
en_US |
dc.identifier.uri |
http://dr.lib.sjp.ac.lk/handle/123456789/7005 |
|
dc.description.abstract |
Attached |
en_US |
dc.description.abstract |
A new naphthoquinone, teratosphaerone A (I), four new naphthalenones, namely, teratosphaerone B (2),
structurally related to I, iso-balticol B (3), iso-balticol B-4,9-acetonide (4), and (+)-balticol C (5), a new furanonaphthalenone,
(3aS,9R,9aS)-1(9a),3(3a),9-hexahydromonosporascone (6), and the known metabolite monosporascone (7) were isolated from
Teratosphaeria sp. FL2137, a fungal strain inhabiting the internal tissue of recently dead but undecomposed foliage of Pinus
clausa. The structures of 1-6 were elucidated on the basis of their spectroscopic data including 2D NMR, and absolute
configurations of 2, 3, and 6 were determined by the modified Mosher's ester method. When evaluated in a panel of five tumor
ceIJlines, metabolites 1 and 7 isolated from a cytotoxic fraction of the extract exhibited moderate selectivity for metastatic breast
adenocarcinoma cell line MDA-MB-231. Of these, 1 showed cytotoxicity to this cell line with an ICso of 1.2 ± 0.1 JiM. |
|
dc.publisher |
Journal of Natural Products |
en_US |
dc.title |
Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa |
en_US |
dc.type |
Article |
en_US |