Abstract:
Insertion of silastic rods containing 25% and 50% atropine adjacent to
the epididymis of rats produced a significant suppression in fertility which
was temporary with the lower dose and permanent with the higher dose.
Both doses also impaired the motility of epididymal spermatozoa and nervemediated
contractile response of isolated vasa deferentia. In addition, the
higher dose caused a significant reduction in the mating frequency. It is
concluded that the antifertility effect resulted primarily from oligospermia due
to dysfunotioning of seminal emission and/or ejaculation.
