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Acute anti-intlammatory activity of evolitrine isolated from Acronychia pedunculata leaves in Wistar rats

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dc.contributor.author Ratnayake, W.M.K.M.
dc.contributor.author Suresh, T.S.
dc.contributor.author Abeysekera, A.M.
dc.contributor.author Salim, N.
dc.contributor.author Chandrika, U.G.
dc.date.accessioned 2019-06-06T05:00:50Z
dc.date.available 2019-06-06T05:00:50Z
dc.date.issued 2018
dc.identifier.citation Ratnayake, W.M.K.M. et al., Acute anti-intlammatory activity of evolitrine isolated from Acronychia pedunculata leaves in Wistar rats, Sixth annual scientific sessions, Sri Lanka Association for Laboratory Animal Acience, 2018 en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/8382
dc.description.abstract Attached en_US
dc.description.abstract Introduction As a result of the adverse effects caused by existing allopathic anti – inflammatory agents, investigations on the efficacy of plant based drugs have been seen as a fruitful research strategy in the search for new alternatives. Acronychia pedunculata (“Ankenda” in Sinhala, Family: Rutaceae) is a medicinal plant which has been used for centuries in traditional/ folk medicine in Sri Lanka. Our previous studies have shown that 70% ethanol extract of leaves of this plant has significant anti-inflammatory activity on the carrageenan induced rat bind paw oedema test model. Objective In the present study, an attempt has been made to evaluate the anti-inflammatory activity of evolitrine which was isolated as a major alkaloid from A. pedunculata leaves, by using the same in-vivo model.
dc.description.abstract Conclusion As evolitrine alone has shown an enhancement of anti-inflammatory activity when compared to the initial crude extract, it was identified as a major anti-inflammatory compound present in A. pedunculata leaves
dc.language.iso en en_US
dc.title Acute anti-intlammatory activity of evolitrine isolated from Acronychia pedunculata leaves in Wistar rats en_US
dc.type Article en_US


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