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In‐Vitro Antioxidant, Hypoglycemic Activity, and Identification of Bioactive Compounds in Phenol‐ Rich Extract from the Marine Red Algae Gracilaria edulis (Gmelin) Silva

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dc.contributor.author Gunathilaka, T.L.
dc.contributor.author Samarakoon, K.W.
dc.contributor.author Ranasinghe, P.
dc.contributor.author Peiris, L.D.C.
dc.date.accessioned 2019-10-29T05:00:29Z
dc.date.available 2019-10-29T05:00:29Z
dc.date.issued 2019
dc.identifier.citation Gunathilaka, T.L. et al., In‐Vitro Antioxidant, Hypoglycemic Activity, and Identification of Bioactive Compounds in Phenol‐ Rich Extract from the Marine Red Algae Gracilaria edulis (Gmelin) Silva, Molecules 2019, 24, 3708 en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/8474
dc.description.abstract Obesity and diabetes are major metabolic disorders which are prevalent worldwide. Algae has played an important role in managing these disorders. In this study, Gracilaria edulis, a marine red algae, was investigated for antioxidant and hypoglycemic potential using in vitro models. Depolysaccharide methanol extract of G. edulis was sequentially partitioned with hexane, chloroform, ethyl acetate, and antioxidants, and hypoglycemic potentials were evaluated using multiple methods. High antioxidant potential was observed in the ethyl acetate fraction in terms of ferric reducing antioxidant power, iron chelating, and DPPH and ABTS radical scavenging activities, while the crude methanol extract exhibited potent oxygen radical‐absorbance capacity. Potent α‐ amylase inhibitory activity was observed in the ethyl acetate fraction, while the ethyl acetate fraction was effective against α‐glucosidase inhibition. Glucose diffusion was inhibited by the ethyl acetate fraction at 180 min, and the highest antiglycation activity was observed in both chloroform and ethyl acetate fractions. Additionally, gas chromatography‐mass spectrometry analysis of the ethyl acetate fraction revealed the presence of several potent anti‐diabetic compounds. In conclusion, G. edulis exhibited promising antidiabetic potential via multiple mechanisms. The ethyl acetate fraction exhibited the strongest hypoglycemic and antiglycation potential among the four fractions, and hence the isolation of active compounds is required to develop leads for new drugs to treat diabetes. en_US
dc.language.iso en en_US
dc.subject Gracillaria edulis; methanol extract; fractionation; α‐amylase; α‐glucosidase; antiglycation; glucose diffusion en_US
dc.title In‐Vitro Antioxidant, Hypoglycemic Activity, and Identification of Bioactive Compounds in Phenol‐ Rich Extract from the Marine Red Algae Gracilaria edulis (Gmelin) Silva en_US
dc.type Article en_US
dc.identifier.doi 10.3390/molecules24203708 en_US


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