Abstract:
Leaves of Argyreia populifoLia Choisy (Convolvulaceae) is used in
traditional medicine for inflammation in joints and Arthropod bites. However,
the pharmacological confirmation for anti-inflammatory activity of
the leaves are lacking. The aim of this study was to evaluate the anti-inflammatory
action of the leaves using carrageenan-induced paw oedema
test in rats. 10 mllkg oral dose of fresh juice of the leaves significantly
impaired the initial phase of the acute inflammatory response (by 33%) in
this model. The juice showed a marked anti-histamine activity when assessed
using histamine-induced vascular permeability test. It was concluded
that the leaf juice has anti-inflammatory activity mediated via antihistamine
action justifying its use in traditional medicine.
