Abstract:
Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried
fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce
silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs).
The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy,
transmission electron microscopy and Fourier transform infrared spectroscopy. The
antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion assays,
broth micro-dilution assays and time-kill kinetics studies against five microbial species,
including Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853),
Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and clinically isolated
methicillin-resistant Staphylococcus aureus (MRSA). The formation of G-AgNPs is a promising
novel approach to enhancing the biological activeness of silver nanoparticles, and to increase
the water solubility of garcinol which creates a broad range of therapeutic applications.
