Abstract:
The aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0–200 μM) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.
