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Treatment with 100 mg/kg and 200 mg/kg body weight of aqueous leaf extract (ALE) of Cardiospermum halicacabum for 30 days
produced a significant dose dependent increase in the sperm counts and sperm motility in both caput and cauda regions. Further,
significant increase in serum testosterone level was evident at all applied doses. However, no significant changes in the weight of
sex organs were observed. Aqueous leaf extract also increased the number of females impregnated, number of implantations, and
number of viable fetuses while decreasing the total number of resorption sites in the pregnant females. However, the total cholesterol
level in the serum remained unchanged and there were no records on renotoxicity; nevertheless ALE exhibited a hepatoprotective
effect. It was concluded that aqueous leaf extract of Cardiospermum halicacabum enhanced sperm concentration, motility, and
testosterone, leading to positive results in fertility
